Vironova Medical's thionation reagent - JBR

The thionation technology is a process for transforming an oxo group (>C=O) in a compound into a thio group (>C=S). JBR is used in organic chemistry to introduce a thio group in various molecules e.g. drugs. By thionating drug compounds, the characteristics can be changed including for example improved stability and delivery, which can result in a more potent or selective agent.

Advantages

Thionation with JBR

  • is an effective and selective methodology
  • allows thionation under mild conditions
  • is cost efficient
  • results in high quality reactions
  • is environmentally better
  • provides a unique opportunity to broadly explore the effects of thionation of drug molecules.

BY THIONATING MOLECULES E.G. DRUGS, UNIQUE AND ADVANTAGEOUS PROPERTIES CAN BE INTRODUCED, LEADING TO A POTENTIALLY IMPROVED COMPOUND.

Applications

The thionation method has been used in our influenza project, resulting in new compounds with antiviral activity against current Influenza stains.